2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1837):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154157
    2’-O-Methyladenosine 5’-monophosphate triethyl ammonium
    		99.35%
    2’-O-Methyladenosine 5’-monophosphate triethyl ammonium is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’-O-Methyladenosine 5’-monophosphate triethyl ammonium
  • HY-124092
    Raluridine
    		99.53%
    Raluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Raluridine
  • HY-13605S
    Cytarabine-d2
    		98.37%
    Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV.
    Cytarabine-d<sub>2</sub>
  • HY-13677S1
    6-Mercaptopurine-13C2,15N
    		Antagonist
    6-Mercaptopurine-13C2,15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
    6-Mercaptopurine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-21601
    5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
    		99.02%
    5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine is an adenosine derivative and can be used as an intermediate for oligonucleotides synthesis.
    5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
  • HY-113135R
    5-Methylcytidine (Standard)
    5-Methylcytidine (Standard) is the analytical standard of 5-Methylcytidine. This product is intended for research and analytical applications. 5-Methylcytidine is a nucleoside compound. 5-Methylcytidine has antiviral activity, and its IC50 against HSV-1 is 0.06 μM.
    5-Methylcytidine (Standard)
  • HY-148166
    L-Inosine
    		99.91%
    L-Inosine is the L-configuration of Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects.
    L-Inosine
  • HY-W013100R
    Cytidine-5'-triphosphate disodium (Standard)
    Cytidine-5'-triphosphate (Cytidine triphosphate) (Standard) disodium is the analytical standard of Cytidine-5'-triphosphate disodium (HY-W013100). This product is intended for research and analytical applications. Cytidine-5'-triphosphate (Cytidine triphosphate; 5'-CTP) disodium is a nucleoside triphosphate, that is invovled in biosynthesis of DNA, RNA and lipid. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate disodium is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate disodium (Standard)
  • HY-138615S1
    Deoxythymidine-5'-triphosphate-15N2 dilithium
    		≥99.0%
    Deoxythymidine-5'-triphosphate-15N2 (dTTP-15N2) dilithium is 15N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate-<sup>15</sup>N<sub>2</sub> dilithium
  • HY-W006103
    I-bu-rG Phosphoramidite
    		≥98.0%
    I-bu-rG Phosphoramidite is a phosphinamide monomer which can be used in the synthesis of nucleotides and nucleic acids.
    I-bu-rG Phosphoramidite
  • HY-152510
    5-(Aminomethyl)uridine
    		98.74%
    5-(Aminomethyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-(Aminomethyl)uridine
  • HY-W539754
    2'-Deoxy-2'-fluoro-4-thiouridine
    		99.61%
    2'-Deoxy-2'-fluoro-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2'-Deoxy-2'-fluoro-4-thiouridine
  • HY-23789
    2′-O-(2-Methoxyethyl)guanosine
    		99.81%
    2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA.
    2′-O-(2-Methoxyethyl)guanosine
  • HY-W114886
    DMT-OMe-rA(Bz)
    DMT-OMe-rA(Bz) is a nucleoside analog.
    DMT-OMe-rA(Bz)
  • HY-126060
    9-Ethylguanine
    		99.84%
    9-Ethylguanine is a modified nucleobase derived from guanine and utilized to investigate the antitumor activity of organometallic complex.
    9-Ethylguanine
  • HY-138615
    Deoxythymidine-5'-triphosphate
    Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate
  • HY-160049
    BC15 aptamer sodium
    BC15 aptamer sodium is an ssDNA aptamer targeting the intracellular protein hnRNP A1, which is highly expressed in cancerous liver tissue. BC15 aptamer sodium specifically recognizes breast cancer cells and can be used to detect cancer cells in other pathological types of breast cancer tissue.
    BC15 aptamer sodium
  • HY-164247
    UnyLinker 12
    UnyLinker 12 is a universal linker that can be used to synthesize oligoribonucleotides.
    UnyLinker 12
  • HY-W154568
    6-MPR
    6-Methylpurine riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-MPR
  • HY-13605R
    Cytarabine (Standard)
    Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine (Standard)